克罗米酚对男性较差促性腺素性功能减退症有效

纽约（华盛顿邮报身体健康版）1同年四日报道：据发表文章在12同年出版的《生育与不育》杂志的一项统计数据指出克罗米苯对部分高促性腺素广泛性急剧下降的成年人人症状有利于。来自伯明翰阿拉巴马大学的该统计数据的第一创作者Scott J. Whitten指导教授在拒绝接受路透新闻网站记者问道是：“临床表现或获得性HH症状在拒绝接受侵害性更大和更为昂贵的疗程（例如注射促性腺激素类）前展开4个同年的克罗米苯试验性疗程是有利于的。”Whitten指导教授和威尔森科学研究了克罗米苯对10名HH成年人人症状（HH是导致成年人人不育的少见因素）是否合理。统计数据称克罗米苯疗程1年后，4名芝诺(氏)综合征症状当中只有一名症状的精子沸点增加而全垂体功能急剧下降症症状的精子欠缺症状外没有得到改善。相反，该统计数据指出3名成年人确诊的临床表现HH成年人人症状经过3个同年克罗米苯的疗程精子沸点有了明显增加。目前为止该组症状已有两名直至了不孕。Whitten指导教授说是：“除非对克罗米苯疗程没有反应，我们不想因为副作用停止对症状使用该药物。”再次创作者归纳说是：“因为先决条件有限，对HH症状促性腺激素阿司匹林和克罗米苯的随机科学研究难以展开，然而利用多第一部的宽松同样标准对症状展开分级显然帮助大幅度验证克罗米苯直至成年人人高不孕的合理性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

编辑：蓝色未来世界

编辑： 张靖